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| Article | ||
| Title | Buprenorphine for neuropathic pain--targeting hyperalgesia | |
| Author | Induru-Raghava-R, Davis-Mellar-P | |
| Article Information | Abstract | |
| Publication | The American journal of hospice & palliative care |
Opioids are well known to relieve severe, acute, and chronic nociceptive pain, but neuropathic pain shows a relatively poor response to opioids. Buprenorphine, a partial mu and ORL-1-receptor agonist, kappa-delta receptor antagonist, interacts with different G proteins than potent mu agonists and hence is not cross-tolerant to standard opioids. Buprenorphine blocks central sensitization (hyperalgesia) that is commonly found with neuropathic pain. We present a patient with neuropathic pain and tactile allodynia in which buprenorphine alleviated the hyperalgesia to a greater extent than pain severity. We found buprenorphine to be effective in reducing hypersensitivity in neuropathic pain when pure mu agonists fail to produce a response or in individuals who are intolerant to pure mu agonists. |
| Reference | BUPP10086 | |
| Year | 2009 | |
| Logged | 10/02/2010 | |
| Volume | 26 | |
| Part | 6 | |
| Pages | 470-3 | |
| ISSN | 1938-2715 | |
| Keywords | ||
| Comparison Drug | ||
| Language | English | |